SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production

SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production

Abstract Background Hepatocellular carcinoma (HCC) is the most major type of primary hepatic cancer. Serine hydroxymethyltransferase 1 (SHMT1) is recently found to play critical roles in human cancers including lung cancer, ovarian cancer and intestinal cancer. However, the expression, function and...

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Bibliographic Details
Main Authors: Changwei Dou, Qiuran Xu, Jie Liu, Yufeng Wang, Zhenyu Zhou, Weifeng Yao, Kai Jiang, Jian Cheng, Chengwu Zhang, Kangsheng Tu
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
SHMT1
Hepatocellular carcinoma
Metastasis
NOX1
Reactive oxygen species
Online Access:http://link.springer.com/article/10.1186/s13046-019-1067-5

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http://link.springer.com/article/10.1186/s13046-019-1067-5

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