Therapeutic Protection Against H. pylori Infection in Mongolian Gerbils by Oral Immunization With a Tetravalent Epitope-Based Vaccine With Polysaccharide Adjuvant

Therapeutic Protection Against H. pylori Infection in Mongolian Gerbils by Oral Immunization With a Tetravalent Epitope-Based Vaccine With Polysaccharide Adjuvant

Urease is an effective target for design of a therapeutic epitope vaccine against Helicobacter pylori (H. pylori). In our previous studies, an epitope vaccine CTB-UE containing Th and B epitopes from H. pylori urease was constructed, and the CTB-UE vaccine could provide therapeutic effect on H. pylo...

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Bibliographic Details
Main Authors: Le Guo, Dantong Hong, Shue Wang, Fan Zhang, Feng Tang, Tao Wu, Yuankui Chu, Hongpeng Liu, Meng He, Hua Yang, Runting Yin, Kunmei Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
Helicobacter pylori
multivalent epitope vaccine
therapeutic vaccine
urease
NAP
CagA
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01185/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01185/full

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