Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern.

Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern.

Successful control of the COVID-19 pandemic depends on vaccines that prevent transmission. The full-length Spike protein is highly immunogenic but the majority of antibodies do not target the virus: ACE2 interface. In an effort to affect the quality of the antibody response focusing it to the recept...

Full description

Bibliographic Details
Main Authors: Gonzalo Almanza, Alex E Clark, Valentina Kouznetsova, Eduardo Olmedillas, Andrea Castro, Igor F Tsigelny, Yan Wu, George F Gao, Sandra L Leibel, William Bray, Erica Ollmann Saphire, Aaron F Carlin, Maurizio Zanetti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010686

Internet

https://doi.org/10.1371/journal.ppat.1010686

Similar Items