Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape.

Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape.

Human astroviruses (HAstV) are understudied positive-strand RNA viruses that cause gastroenteritis mostly in children and the elderly. Three clades of astroviruses, classic, MLB-type and VA-type have been reported in humans. One limitation towards a better understanding of these viruses has been the...

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Bibliographic Details
Main Authors: Abimbola O Kolawole, Carmen Mirabelli, David R Hill, Sophia A Svoboda, Andrew B Janowski, Karla D Passalacqua, Benancio N Rodriguez, Michael K Dame, Pamela Freiden, Ryan P Berger, Diem-Lan Vu, Myra Hosmillo, Mary X D O'Riordan, Stacey Schultz-Cherry, Susana Guix, Jason R Spence, David Wang, Christiane E Wobus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008057

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https://doi.org/10.1371/journal.ppat.1008057

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