Metabolic Profiling of the Uncaria Hook Alkaloid Geissoschizine Methyl Ether in Rat and Human Liver Microsomes Using High-Performance Liquid Chromatography with Tandem Mass Spectrometry

Metabolic Profiling of the Uncaria Hook Alkaloid Geissoschizine Methyl Ether in Rat and Human Liver Microsomes Using High-Performance Liquid Chromatography with Tandem Mass Spectrometry

Geissoschizine methyl ether (GM) is an indole alkaloid found in Uncaria hook, which is a galenical constituent of yokukansan, a traditional Japanese medicine. GM has been identified as the active component responsible for anti-aggressive effects. In this study, the metabolic profiling of GM in rat a...

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Bibliographic Details
Main Authors: Hirotaka Kushida, Takashi Matsumoto, Yasushi Igarashi, Hiroaki Nishimura, Junko Watanabe, Kazuya Maemura, Yoshio Kase
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Molecules
Subjects:
geissoschizine methyl ether
Uncaria hook
metabolic profile
LC/MS/MS
rat liver microsome
human liver microsome
Online Access:http://www.mdpi.com/1420-3049/20/2/2100

Internet

http://www.mdpi.com/1420-3049/20/2/2100

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