Genetic associations with longevity are on average stronger in females than in males

Genetic associations with longevity are on average stronger in females than in males

It is long observed that females tend to live longer than males in nearly every country. However, the underlying mechanism remains elusive. In this study, we discovered that genetic associations with longevity are on average stronger in females than in males through bio-demographic analyses of genom...

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Bibliographic Details
Main Authors: Yi Zeng, Huashuai Chen, Xiaomin Liu, Zijun Song, Yao Yao, Xiaoyan Lei, Xiaozhen Lv, Lingguo Cheng, Zhihua Chen, Chen Bai, Zhaoxue Yin, Yuebin Lv, Jiehua Lu, Jianxin Li, Kenneth C. Land, Anatoliy Yashin, Angela M. O'Rand, Liang Sun, Ze Yang, Wei Tao, Jun Gu, William Gottschalk, Qihua Tan, Kaare Christensen, Therese Hesketh, Xiao-Li Tian, Huanming Yang, Viviana Egidi, Graziella Caselli, Jean-Marie Robine, Huali Wang, Xiaoming Shi, James W. Vaupel, Michael W. Lutz, Chao Nie, Junxia Min
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Longevity
Male-female health-survival paradox
sex differences
Polygenic risk score analysis
Centenarians
Precise healthcare for males and females
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023108991

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http://www.sciencedirect.com/science/article/pii/S2405844023108991

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