A Novel Role for the Interleukin-1 Receptor Axis in Resistance to Anti-EGFR Therapy

A Novel Role for the Interleukin-1 Receptor Axis in Resistance to Anti-EGFR Therapy

Cetuximab (CTX) is a monoclonal antibody targeting the epidermal growth factor receptor (EGFR), commonly used to treat patients with metastatic colorectal cancer (mCRC). Unfortunately, objective remissions occur only in a minority of patients and are of short duration, with a population of cells sur...

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Bibliographic Details
Main Authors: Valerio Gelfo, Martina Mazzeschi, Giada Grilli, Moshit Lindzen, Spartaco Santi, Gabriele D’Uva, Balázs Győrffy, Andrea Ardizzoni, Yosef Yarden, Mattia Lauriola
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
cetuximab
colon cancer
inflammation
colonspheres
MAPK
consensus molecular subtype
resistance
Online Access:http://www.mdpi.com/2072-6694/10/10/355

Internet

http://www.mdpi.com/2072-6694/10/10/355

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