Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis and in silico study

Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis and in silico study

Spirochromanes incorporating Schiff's bases and semicarbazones 4a-e and 5a-j were synthesizedand analyzed for their potential antiproliferative activity using four human cancer cell lines (MCF-7, HCT-116, PC3, and A549). Compounds 5a, 5b and 5g possessed the highest antiproliferative activity a...

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Bibliographic Details
Main Authors: Dina I.A. Othman, Abdelrahman Hamdi, Walaa M. Elhusseiny, Adel S. El-Azab, Ahmed H. Bakheit, Mohamed Hefnawy, Alaa A.-M. Abdel-Aziz
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Saudi Pharmaceutical Journal
Subjects:
Spirochromane
Schiff's bases
Synthesis
Antiproliferative activity
Enzymatic assay
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423002980

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http://www.sciencedirect.com/science/article/pii/S1319016423002980

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