The RNA export and RNA decay complexes THO and TRAMP prevent transcription-replication conflicts, DNA breaks, and CAG repeat contractions.

The RNA export and RNA decay complexes THO and TRAMP prevent transcription-replication conflicts, DNA breaks, and CAG repeat contractions.

Expansion of structure-forming CAG/CTG repetitive sequences is the cause of several neurodegenerative disorders and deletion of repeats is a potential therapeutic strategy. Transcription-associated mechanisms are known to cause CAG repeat instability. In this study, we discovered that Thp2, an RNA e...

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Bibliographic Details
Main Authors: Rebecca E Brown, Xiaofeng A Su, Stacey Fair, Katherine Wu, Lauren Verra, Robyn Jong, Kristin Andrykovich, Catherine H Freudenreich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001940

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https://doi.org/10.1371/journal.pbio.3001940

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