High baseline tumor burden‐associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2‐STAT3‐PD‐L1 pathway

High baseline tumor burden‐associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2‐STAT3‐PD‐L1 pathway

Abstract Background Several clinical studies have uncovered a negative correlation between baseline tumor burden and the efficacy of immune checkpoint inhibitor (ICI) treatment. This study aimed to uncover the specific mechanisms underlying the difference in sensitivity to ICI treatment between tumo...

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Bibliographic Details
Main Authors: Zhaowei Wen, Huiying Sun, Zhihua Zhang, Yannan Zheng, Siting Zheng, Jianping Bin, Yulin Liao, Min Shi, Rui Zhou, Wangjun Liao
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Cancer Communications
Subjects:
CD8+ T cell
IGFBP2
immune checkpoint inhibitor
macrophage
PD‐L1
STAT3
Online Access:https://doi.org/10.1002/cac2.12420

Internet

https://doi.org/10.1002/cac2.12420

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