Bacterial expression of a designed single‐chain IL‐10 prevents severe lung inflammation

Bacterial expression of a designed single‐chain IL‐10 prevents severe lung inflammation

Abstract Interleukin‐10 (IL‐10) is an anti‐inflammatory cytokine that is active as a swapped domain dimer and is used in bacterial therapy of gut inflammation. IL‐10 can be used as treatment of a wide range of pulmonary diseases. Here we have developed a non‐pathogenic chassis (CV8) of the human lun...

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Bibliographic Details
Main Authors: Ariadna Montero‐Blay, Javier Delgado Blanco, Irene Rodriguez‐Arce, Claire Lastrucci, Carlos Piñero‐Lambea, Maria Lluch‐Senar, Luis Serrano
Format: Article
Language:English
Published: Springer Nature 2023-01-01
Series:Molecular Systems Biology
Subjects:
infection
interleukin
live biotherapeutics
mycoplasma
protein engineering
Online Access:https://doi.org/10.15252/msb.202211037

Internet

https://doi.org/10.15252/msb.202211037

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