Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents

Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents

This article presents the synthesis of new derivatives of spirooxindole-spiropiperidinone- pyrrolidines 6a–j and spirooxindole-spiropiperidinone-pyrrolizines 8a–j, through a 1,3-dipolar cycloaddition reaction of azomethineylides generated from isatin, sarcosine, and l-proline, through a decarboxylat...

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Bibliographic Details
Main Authors: Huwaida M. E. Hassaneen, Elshimaa M. Eid, Hamid A. Eid, Thoraya A. Farghaly, Yahia Nasser Mabkhot
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Molecules
Subjects:
isatin
sarcosine
l-proline
azomethineylide
1,3-dipolar cycloaddition
antimicrobial activity
Online Access:http://www.mdpi.com/1420-3049/22/3/357

Internet

http://www.mdpi.com/1420-3049/22/3/357

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