Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents
This article presents the synthesis of new derivatives of spirooxindole-spiropiperidinone- pyrrolidines 6a–j and spirooxindole-spiropiperidinone-pyrrolizines 8a–j, through a 1,3-dipolar cycloaddition reaction of azomethineylides generated from isatin, sarcosine, and l-proline, through a decarboxylat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/22/3/357 |
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| author | Huwaida M. E. Hassaneen Elshimaa M. Eid Hamid A. Eid Thoraya A. Farghaly Yahia Nasser Mabkhot |
| author_facet | Huwaida M. E. Hassaneen Elshimaa M. Eid Hamid A. Eid Thoraya A. Farghaly Yahia Nasser Mabkhot |
| author_sort | Huwaida M. E. Hassaneen |
| collection | DOAJ |
| description | This article presents the synthesis of new derivatives of spirooxindole-spiropiperidinone- pyrrolidines 6a–j and spirooxindole-spiropiperidinone-pyrrolizines 8a–j, through a 1,3-dipolar cycloaddition reaction of azomethineylides generated from isatin, sarcosine, and l-proline, through a decarboxylative route with dipolarophile 4a–j. All of the newly synthesized compounds were evaluated for their antimicrobial activities and their minimum inhibitory concentration (MIC) against most of the test organisms. The tested compounds displayed excellent activity against all of the tested microorganisms. |
| first_indexed | 2024-12-14T00:50:06Z |
| format | Article |
| id | doaj.art-4e68302d465e438d8b9a1c75d3f94d9d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T00:50:06Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4e68302d465e438d8b9a1c75d3f94d9d2022-12-21T23:23:54ZengMDPI AGMolecules1420-30492017-02-0122335710.3390/molecules22030357molecules22030357Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial AgentsHuwaida M. E. Hassaneen0Elshimaa M. Eid1Hamid A. Eid2Thoraya A. Farghaly3Yahia Nasser Mabkhot4Chemistry Department, Faculty of Science, Cairo University, Giza 12613, EgyptChemistry Department, Faculty of Science, Cairo University, Giza 12613, EgyptChemistry Department, Faculty of Science, Cairo University, Giza 12613, EgyptChemistry Department, Faculty of Science, Cairo University, Giza 12613, EgyptDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh-11451, Saudi ArabiaThis article presents the synthesis of new derivatives of spirooxindole-spiropiperidinone- pyrrolidines 6a–j and spirooxindole-spiropiperidinone-pyrrolizines 8a–j, through a 1,3-dipolar cycloaddition reaction of azomethineylides generated from isatin, sarcosine, and l-proline, through a decarboxylative route with dipolarophile 4a–j. All of the newly synthesized compounds were evaluated for their antimicrobial activities and their minimum inhibitory concentration (MIC) against most of the test organisms. The tested compounds displayed excellent activity against all of the tested microorganisms.http://www.mdpi.com/1420-3049/22/3/357isatinsarcosinel-prolineazomethineylide1,3-dipolar cycloadditionantimicrobial activity |
| spellingShingle | Huwaida M. E. Hassaneen Elshimaa M. Eid Hamid A. Eid Thoraya A. Farghaly Yahia Nasser Mabkhot Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents Molecules isatin sarcosine l-proline azomethineylide 1,3-dipolar cycloaddition antimicrobial activity |
| title | Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents |
| title_full | Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents |
| title_fullStr | Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents |
| title_full_unstemmed | Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents |
| title_short | Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents |
| title_sort | facial regioselective synthesis of novel bioactive spiropyrrolidine pyrrolizine oxindole derivatives via a three components reaction as potential antimicrobial agents |
| topic | isatin sarcosine l-proline azomethineylide 1,3-dipolar cycloaddition antimicrobial activity |
| url | http://www.mdpi.com/1420-3049/22/3/357 |
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