Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation

Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation

We analyzed NMDA receptor subunit mRNAs, proteins, and anchoring proteins in mice transgenic for exon 1 of the HD gene. R6/2 mice had decreased levels of mRNAs encoding ε1 and ε2 NMDA receptor subunits (mouse orthologs of rat NR2A and NR2B subunits), but not the ζ1 subunit (mouse ortholog of NR1), a...

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Bibliographic Details
Main Authors: Ruth Luthi-Carter, Barbara L Apostol, Anthone W Dunah, Molly M DeJohn, Laurie A Farrell, Gillian P Bates, Anne B Young, David G Standaert, Leslie M Thompson, Jang-Ho J Cha
Format: Article
Language:English
Published: Elsevier 2003-12-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001724

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http://www.sciencedirect.com/science/article/pii/S0969996103001724

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