Male DAT Val559 Mice Exhibit Compulsive Behavior under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes

Male DAT Val559 Mice Exhibit Compulsive Behavior under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes

Identified across multiple psychiatric disorders, the dopamine (DA) transporter (DAT) Ala559Val substitution triggers non-vesicular, anomalous DA efflux (ADE), perturbing DA neurotransmission and behavior. We have shown that DAT Val559 mice display a waiting impulsivity and changes in cognitive perf...

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Bibliographic Details
Main Authors: Adele Stewart, Gwynne L. Davis, Lorena B. Areal, Maximilian J. Rabil, Vuong Tran, Felix P. Mayer, Randy D. Blakely
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
psychiatric disorder
compulsivity
impulsivity
dopamine transporter
animal model
instrumental learning
Online Access:https://www.mdpi.com/2073-4409/11/24/4059

Internet

https://www.mdpi.com/2073-4409/11/24/4059

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