CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing

CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing

Summary: In eukaryotic genomes, heterochromatin is targeted by RNAi machinery and/or by pathways requiring RNA elimination and transcription termination factors. However, a direct connection between termination machinery and RNA polymerase II (RNAPII) transcriptional activity at heterochromatic loci...

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Bibliographic Details
Main Authors: Tommy V. Vo, Jothy Dhakshnamoorthy, Madeline Larkin, Martin Zofall, Gobi Thillainadesan, Vanivilasini Balachandran, Sahana Holla, David Wheeler, Shiv I.S. Grewal
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719307545

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http://www.sciencedirect.com/science/article/pii/S2211124719307545

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