Towards a better understanding of thermally treated polycarbophil matrix tablets for controlled release

Towards a better understanding of thermally treated polycarbophil matrix tablets for controlled release

Polycarbophil (POL), a polyacrylic acid cross-linked with divinyl glycol, is widely used in semisolid and solid dosage forms. When undergoing a thermal treatment in the range 120–160 °C, POL shows interesting morphological modifications, related to changes in physical properties, such as swelling of...

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Bibliographic Details
Main Authors: Sara Baldassari, Paola Cirrincione, Giorgia Ailuno, Giuliana Drava, Silvia Arpicco, Gabriele Caviglioli
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Cross-linked polyacrylic polymer
Thermal treatment
Shrinking
Glass transition
Solid dosage forms
Matrix tablet
Online Access:http://www.sciencedirect.com/science/article/pii/S259015672100027X

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http://www.sciencedirect.com/science/article/pii/S259015672100027X

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