Effective delivery of osteopontin small interference RNA using exosomes suppresses liver fibrosis via TGF-β1 signaling

Effective delivery of osteopontin small interference RNA using exosomes suppresses liver fibrosis via TGF-β1 signaling

Objective and aims: Osteopontin (OPN), an oxidant stress sensitive cytokine, plays a central role in liver fibrosis. While OPN expression can be reduced by small interfering RNA (siRNA), the challenge to deliver siRNA safely and effectively into liver remains unresolved. Exosomes are promising natur...

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Bibliographic Details
Main Authors: Min Tang, Cheng Guo, Mengxue Sun, Hao Zhou, Xin Peng, Jianli Dai, Qin Ding, Ying Wang, Changqing Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
liver fibrosis
osteopontin
small interfering RNA
exosome-mediated delivery
TGF-β1 signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.882243/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.882243/full

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