Extracellular Vesicles from Steatotic Hepatocytes Provoke Pro-Fibrotic Responses in Cultured Stellate Cells

Extracellular Vesicles from Steatotic Hepatocytes Provoke Pro-Fibrotic Responses in Cultured Stellate Cells

Hepatic steatosis and chronic hepatocyte damage ultimately lead to liver fibrosis. Key pathophysiological steps are the activation and transdifferentiation of hepatic stellate cells. We assessed the interplay between hepatocytes and hepatic stellate cells under normal and steatotic conditions. We hy...

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Bibliographic Details
Main Authors: Maria Teresa Koenen, Elisa Fabiana Brandt, Dawid Marcin Kaczor, Tim Caspers, Alexandra Catharina Anna Heinzmann, Petra Fischer, Daniel Heinrichs, Theresa Hildegard Wirtz, Christian Trautwein, Rory R Koenen, Marie-Luise Berres
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomolecules
Subjects:
stellate cell
liver fibrosis
extracellular vesicles
non-alcoholic fatty liver disease
metabolic-associated fatty liver disease
Online Access:https://www.mdpi.com/2218-273X/12/5/698

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https://www.mdpi.com/2218-273X/12/5/698

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