Synthesis and Biological Evaluation of New Isoxazolyl Steroids as Anti-Prostate Cancer Agents

Synthesis and Biological Evaluation of New Isoxazolyl Steroids as Anti-Prostate Cancer Agents

Steroids with a nitrogen-containing heterocycle in the side chain are known as effective inhibitors of androgen signaling and/or testosterone biosynthesis, thus showing beneficial effects for the treatment of prostate cancer. In this work, a series of 3β-hydroxy-5-ene steroids, containing an isoxazo...

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Bibliographic Details
Main Authors: Anton S. Rudovich, Miroslav Peřina, Anastasiya V. Krech, Maria Y. Novozhilova, Anastasia M. Tumilovich, Tatyana V. Shkel, Irina P. Grabovec, Miroslav Kvasnica, Lukáš Mada, Maria G. Zavialova, Arif R. Mekhtiev, Radek Jorda, Vladimir N. Zhabinskii, Vladimir A. Khripach
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
androgen signaling
androgen receptor
CYP17A1
isoxazoles
Weinreb amide
Online Access:https://www.mdpi.com/1422-0067/23/21/13534

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https://www.mdpi.com/1422-0067/23/21/13534

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