Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3–eIF3h interaction

Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3–eIF3h interaction

Abstract Background Exosomes have emerged as vital biomarkers of multiple cancers and contain abundant circular RNAs (circRNAs). However, the potential for exosomal circRNAs to be used in diagnostics and their molecular mechanism of action in colorectal cancer (CRC) remain unclear. Methods CRC-speci...

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Bibliographic Details
Main Authors: Rui Zheng, Ke Zhang, Shanyue Tan, Fang Gao, Yajie Zhang, Wenxia Xu, Huabin Wang, Dongying Gu, Lingjun Zhu, Shuwei Li, Haiyan Chu, Zhengdong Zhang, Lingxiang Liu, Mulong Du, Meilin Wang
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Molecular Cancer
Subjects:
Colorectal cancer
Exosomal circLPAR1
Biomarker
METTL3–eIF3h interaction
BRD4
Online Access:https://doi.org/10.1186/s12943-021-01471-y

Internet

https://doi.org/10.1186/s12943-021-01471-y

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