Lipid nanoparticles with PEG-variant surface modifications mediate genome editing in the mouse retina

Lipid nanoparticles with PEG-variant surface modifications mediate genome editing in the mouse retina

Abstract Ocular delivery of lipid nanoparticle (LNPs) packaged mRNA can enable efficient gene delivery and editing. We generated LNP variants through the inclusion of positively charged-amine-modified polyethylene glycol (PEG)-lipids (LNPa), negatively charged-carboxyl-(LNPz) and carboxy-ester (LNPx...

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Bibliographic Details
Main Authors: Milan Gautam, Antony Jozic, Grace Li-Na Su, Marco Herrera-Barrera, Allison Curtis, Sebastian Arrizabalaga, Wayne Tschetter, Renee C. Ryals, Gaurav Sahay
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42189-3

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https://doi.org/10.1038/s41467-023-42189-3

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