K-Ras-ERK1/2 accelerates lung cancer cell development via mediating H3K18ac through the MDM2-GCN5-SIRT7 axis

K-Ras-ERK1/2 accelerates lung cancer cell development via mediating H3K18ac through the MDM2-GCN5-SIRT7 axis

Context: H3K18ac is linked to gene expression and DNA damage. Nevertheless, whether H3K18ac participates in regulating Ras-ERK1/2-affected lung cancer cell phenotypes remains unclear. Objective: We explored the effects of H3K18ac on Ras-ERK1/2-affected lung cancer cell phenotypes. Material and metho...

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Bibliographic Details
Main Authors: Ziming Cheng, Xiufeng Li, Shizhen Hou, Yubing Wu, Yi Sun, Bing Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Pharmaceutical Biology
Subjects:
k-ras
nci-h2126 cells
cell proliferation
migration
erk1/2 downstream factors
Online Access:http://dx.doi.org/10.1080/13880209.2019.1672756

Internet

http://dx.doi.org/10.1080/13880209.2019.1672756

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