Baricitinib with cyclosporine eliminates acute graft rejection in fully mismatched skin and heart transplant models

Baricitinib with cyclosporine eliminates acute graft rejection in fully mismatched skin and heart transplant models

Solid organ transplant represents a potentially lifesaving procedure for patients suffering from end-stage heart, lung, liver, and kidney failure. However, rejection remains a significant source of morbidity and immunosuppressive medications have significant toxicities. Janus kinase (JAK) inhibitors...

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Bibliographic Details
Main Authors: Ramzi Abboud, Sena Kim, Karl Staser, Reyka G. Jayasinghe, Sora Lim, Parmeshwar Amatya, C. Corbin Frye, Benjamin Kopecky, Julie Ritchey, Feng Gao, Kory Lavine, Daniel Kreisel, John F. DiPersio, Jaebok Choi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
baricitinib
JAK
Solid organ
graft
cyclosporine
immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1264496/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1264496/full

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