Recellularized Colorectal Cancer Patient-Derived Scaffolds as In Vitro Pre-Clinical 3D Model for Drug Screening

Recellularized Colorectal Cancer Patient-Derived Scaffolds as In Vitro Pre-Clinical 3D Model for Drug Screening

Colorectal cancer (CRC) shows highly ineffective therapeutic management. An urgent unmet need is the random assignment to adjuvant chemotherapy of high-risk stage II and stage III CRC patients without any predictive factor of efficacy. In the field of drug discovery, a critical step is the preclinic...

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Bibliographic Details
Main Authors: Francesca Sensi, Edoardo D’Angelo, Martina Piccoli, Piero Pavan, Francesca Mastrotto, Paolo Caliceti, Andrea Biccari, Diana Corallo, Luca Urbani, Matteo Fassan, Gaya Spolverato, Pietro Riello, Salvatore Pucciarelli, Marco Agostini
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
3d culture model
colorectal cancer
extracellular matrix
decellularization
drug test
response to treatment
Online Access:https://www.mdpi.com/2072-6694/12/3/681

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https://www.mdpi.com/2072-6694/12/3/681

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