An Attenuated Zika Virus Encoding Non-Glycosylated Envelope (E) and Non-Structural Protein 1 (NS1) Confers Complete Protection against Lethal Challenge in a Mouse Model

An Attenuated Zika Virus Encoding Non-Glycosylated Envelope (E) and Non-Structural Protein 1 (NS1) Confers Complete Protection against Lethal Challenge in a Mouse Model

Zika virus (ZIKV), a mosquito-transmitted flavivirus, emerged in the last decade causing serious human diseases, including congenital microcephaly in newborns and Guillain-Barré syndrome in adults. Although many vaccine platforms are at various stages of development, no licensed vaccines ar...

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Bibliographic Details
Main Authors: Arun S. Annamalai, Aryamav Pattnaik, Bikash R. Sahoo, Zack P. Guinn, Brianna L. Bullard, Eric A. Weaver, David Steffen, Sathish Kumar Natarajan, Thomas M. Petro, Asit K. Pattnaik
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Vaccines
Subjects:
Zika virus
NS1 protein
glycosylation
attenuation
vaccine candidate
Online Access:https://www.mdpi.com/2076-393X/7/3/112

Internet

https://www.mdpi.com/2076-393X/7/3/112

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