Derivation of functional thymic epithelial organoid lines from adult murine thymus

Derivation of functional thymic epithelial organoid lines from adult murine thymus

Summary: Thymic epithelial cells (TECs) orchestrate T cell development by imposing positive and negative selection on thymocytes. Current studies on TEC biology are hampered by the absence of long-term ex vivo culture platforms, while the cells driving TEC self-renewal remain to be identified. Here,...

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Bibliographic Details
Main Authors: Sangho Lim, Gijs J. F. van Son, Ni Luh Wisma Eka Yanti, Amanda Andersson-Rolf, Sam Willemsen, Jeroen Korving, Hong-Gyun Lee, Harry Begthel, Hans Clevers
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724003474

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http://www.sciencedirect.com/science/article/pii/S2211124724003474

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