Regulation of antigen-specific T cell infiltration and spatial architecture in multiple myeloma and premalignancy

Regulation of antigen-specific T cell infiltration and spatial architecture in multiple myeloma and premalignancy

Entry of antigen-specific T cells into human tumors is critical for immunotherapy, but the underlying mechanisms are poorly understood. Here, we combined high-dimensional spatial analyses with in vitro and in vivo modeling to study the mechanisms underlying immune infiltration in human multiple myel...

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Bibliographic Details
Main Authors: M. Hope Robinson, Nancy Y. Villa, David L. Jaye, Ajay K. Nooka, Alyssa Duffy, Samuel S. McCachren, Julia Manalo, Jeffrey M. Switchenko, Sierra Barnes, Sayalee Potdar, Maryam I. Azeem, Ava A. Horvat, Vaunita C. Parihar, Jingjing Gong, Yan Liang, Geoffrey H. Smith, Vikas A. Gupta, Lawrence H. Boise, Jonathan L. Kaufman, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, Kavita M. Dhodapkar, Madhav V. Dhodapkar
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-08-01
Series:The Journal of Clinical Investigation
Subjects:
Hematology
Immunology
Online Access:https://doi.org/10.1172/JCI167629

Internet

https://doi.org/10.1172/JCI167629

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