The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly

The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly

Summary: Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of kinases that control fundamental processes, including cell growth, DNA damage repair, and gene expression. Although their regulation and activities are well characterized, little is known about how PIKKs fold and assemble...

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Bibliographic Details
Main Authors: Damien Toullec, Alberto Elías-Villalobos, Céline Faux, Ambre Noly, Gwendaline Lledo, Martial Séveno, Dominique Helmlinger
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
PIKKs
multimeric complex
chaperone
translation
TTT
HSP90
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013346

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http://www.sciencedirect.com/science/article/pii/S2211124721013346

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