ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3

ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3

We hypothesized that reduction/loss of very long chain PUFAs (VLC-PUFAs) due to mutations in the ELOngase of very long chain fatty acid-4 (ELOVL4) protein contributes to retinal degeneration in autosomal dominant Stargardt-like macular dystrophy (STGD3) and age-related macular degeneration; hence, i...

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Bibliographic Details
Main Authors: Man Yu, Aaron Benham, Sreemathi Logan, R. Steven Brush, Md Nawajes A. Mandal, Robert E. Anderson, Martin-Paul Agbaga
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Journal of Lipid Research
Subjects:
elongase of very long chain fatty acids
very long chain polyunsaturated fatty acids
chylomicrons
fatty acids/biosynthesis
juvenile autosomal dominant Stargardt-like macular dystrophy type 3 disease
arachidonic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520413641

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http://www.sciencedirect.com/science/article/pii/S0022227520413641

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