Design, Synthesis, and Antitumor Activity of Isoliquiritigenin Amino Acid Ester Derivatives

Isoliquiritigenin (ISL) is a chalcone that has shown great potential in the treatment of cancer. However, its relatively weak activity and low water solubility limit its clinical application. In this study, we designed and synthesized 21 amino acid ester derivatives of ISL and characterized the comp...

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Bibliographic Details
Main Authors: Chi Liu, Xinyue Liu, Qing Ma, Fengyan Su, Enbo Cai
Format: Article
Language:English
Published: MDPI AG 2024-06-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/29/11/2641