Automated measurement of lamellar thickness in human bone using polarized light microscopy

Lamellar bone formed in individuals with moderate and severe osteogenesis imperfecta (OI) is often composed of lamellae that are structurally abnormal. Measuring the thickness of these lamellae can be helpful in assessing the effect of specific collagen and collagen-related mutations on OI bone synt...

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Bibliographic Details
Main Authors: Nicolas Ryan, Sandra J Shefelbine, Frederic Shapiro
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:MethodsX
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2215016123004247