Treatment with specific and pan-plasma membrane calcium ATPase (PMCA) inhibitors reduces malaria parasite growth in vitro and in vivo

Treatment with specific and pan-plasma membrane calcium ATPase (PMCA) inhibitors reduces malaria parasite growth in vitro and in vivo

Abstract Background Rapid emergence of Plasmodium resistance to anti-malarial drug mainstays has driven a continual effort to discover novel drugs that target different biochemical pathway (s) during infection. Plasma membrane Calcium + 2 ATPase (PMCA4), a novel plasma membrane protein that regulate...

Full description

Bibliographic Details
Main Authors: Puji B. S. Asih, Josephine E. Siregar, Farahana K. Dewayanti, Normalita E. Pravitasari, Ismail E. Rozi, Andita F. M. Rizki, Rifqi Risandi, Kevin N. Couper, Delvac Oceandy, Din Syafruddin
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Malaria Journal
Subjects:
PMCA4 inhibitors
Antimalarial activity
Plasmodium falciparum
Plasmodium berghei
Plasmodium yoelii
In vitro and in vivo
Online Access:https://doi.org/10.1186/s12936-022-04228-0

Internet

https://doi.org/10.1186/s12936-022-04228-0

Similar Items