Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response

Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response

Acromegaly is caused by excess growth hormone (GH) produced by a pituitary tumor. First-generation somatostatin receptor ligands (SRLs) are the first-line treatment. Several studies have linked E-cadherin loss and epithelial-mesenchymal transition (EMT) with resistance to SRLs. Our aim was to study...

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Bibliographic Details
Main Authors: Joan Gil, Montserrat Marques-Pamies, Elena Valassi, Araceli García-Martínez, Guillermo Serra, Cristina Hostalot, Carmen Fajardo-Montañana, Cristina Carrato, Ignacio Bernabeu, Mónica Marazuela, Helena Rodríguez-Lloveras, Rosa Cámara, Isabel Salinas, Cristina Lamas, Betina Biagetti, Andreu Simó-Servat, Susan M. Webb, Antonio Picó, Mireia Jordà, Manel Puig-Domingo
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biomedicines
Subjects:
epithelial-mesenchymal transition
acromegaly
somatostatin receptor ligands (SRLs)
somatostatin analogs (SSAs)
RORC
SNAI1
Online Access:https://www.mdpi.com/2227-9059/10/2/460

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https://www.mdpi.com/2227-9059/10/2/460

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