MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus

MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus

Abstract Diabetic cardiomyopathy (DCM) is a major contributor to mortality in diabetic patients, characterized by a multifaceted pathogenesis and limited therapeutic options. While lactate, a byproduct of glycolysis, is known to be significantly elevated in type 2 diabetes, its specific role in DCM...

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Bibliographic Details
Main Authors: Xiu Mei Ma, Kang Geng, Peng Wang, Zongzhe Jiang, Betty Yuen-Kwan Law, Yong Xu
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cardiovascular Diabetology
Subjects:
MCT4
Lactate
Lipotoxicity
Inflammation
Diabetic cardiomyopathy
Online Access:https://doi.org/10.1186/s12933-024-02178-2

Internet

https://doi.org/10.1186/s12933-024-02178-2

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