An Antibacterial Peptide with High Resistance to Trypsin Obtained by Substituting <span style="font-variant: small-caps">d</span>-Amino Acids for Trypsin Cleavage Sites

An Antibacterial Peptide with High Resistance to Trypsin Obtained by Substituting <span style="font-variant: small-caps">d</span>-Amino Acids for Trypsin Cleavage Sites

The poor stability of antibacterial peptide to protease limits its clinical application. Among these limitations, trypsin mainly exists in digestive tract, which is an insurmountable obstacle to orally delivered peptides. OM19R is a random curly polyproline cationic antimicrobial peptide, which has...

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Bibliographic Details
Main Authors: Xiaoou Zhao, Mengna Zhang, Inam Muhammad, Qi Cui, Haipeng Zhang, Yu Jia, Qijun Xu, Lingcong Kong, Hongxia Ma
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Antibiotics
Subjects:
antimicrobial peptides
trypsin
<span style="font-variant: small-caps">d</span>-amino acids
stability
mechanism
Online Access:https://www.mdpi.com/2079-6382/10/12/1465

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https://www.mdpi.com/2079-6382/10/12/1465

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