Evaluation of Circulating and Archived HIV-1 Integrase Drug-Resistance Variants among Patients on Third-Line ART in Cameroon: Implications for Dolutegravir-Containing Regimens in Resource-Limited Settings

Evaluation of Circulating and Archived HIV-1 Integrase Drug-Resistance Variants among Patients on Third-Line ART in Cameroon: Implications for Dolutegravir-Containing Regimens in Resource-Limited Settings

ABSTRACT To ensure the long-term efficacy of dolutegravir (DTG), we evaluated the genotypic profile in viral reservoirs among patients on third-line (3L) antiretroviral therapy (ART) in Cameroon, according to prior exposure to raltegravir (RAL). A facility-based study was conducted from May through...

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Bibliographic Details
Main Authors: Joseph Fokam, Ezechiel Ngoufack Jagni Semengue, Evariste Molimbou, Naomi-Karell Etame, Maria Mercedes Santoro, Désiré Takou, Leonella Mossiang, Alain Patrice Meledie, Collins Ambe Chenwi, Bouba Yagai, Alex Durand Nka, Beatrice Dambaya, Georges Teto, Aude Christelle Ka’e, Grâce Angong Beloumou, Sandrine Claire Djupsa Ndjeyep, Nadine Fainguem, Aissatou Abba, Aurelie Minelle Ngueko Kengni, Michel Carlos Tommo Tchouaket, Nounouce Pamen Bouba, Serge-Clotaire Billong, Rina Djubgang, Edith Temgoua Saounde, Samuel Martin Sosso, Charles Kouanfack, Anne-Cecile Zoung-Kanyi Bissek, Emmanuel Eben-Moussi, Vittorio Colizzi, Carlo-Federico Perno, Francesca Ceccherini-Silberstein, Alexis Ndjolo
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
archived resistance
third-line ART
dolutegravir
raltegravir
Cameroon
HIV-1
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03420-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03420-22

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