Regulatory effects of IRF4 on immune cells in the tumor microenvironment

Regulatory effects of IRF4 on immune cells in the tumor microenvironment

The tumor microenvironment (TME) is implicated in tumorigenesis, chemoresistance, immunotherapy failure and tumor recurrence. Multiple immunosuppressive cells and soluble secreted cytokines together drive and accelerate TME disorders, T cell immunodeficiency and tumor growth. Thus, it is essential t...

Full description

Bibliographic Details
Main Authors:	Jing Lu, Taotao Liang, Ping Li, Qingsong Yin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Series:	Frontiers in Immunology
Subjects:	IRF4 tumor microenvironment immunosuppressive cells T cell exhaustion immunoregulation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1086803/full

Similar Items

IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities
by: Dennis Christoph Harrer, et al.
Published: (2023-05-01)

Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future Perspectives
by: Laurenz Nagl, et al.
Published: (2020-08-01)

PROS1 shapes the immune-suppressive tumor microenvironment and predicts poor prognosis in glioma
by: Jinxiang Wang, et al.
Published: (2023-01-01)

Identification of IRF-associated molecular subtypes in clear cell renal cell carcinoma to characterize immunological characteristics and guide therapy
by: Can Chen, et al.
Published: (2023-01-01)

CREM Is Correlated With Immune-Suppressive Microenvironment and Predicts Poor Prognosis in Gastric Adenocarcinoma
by: Kuai Yu, et al.
Published: (2021-12-01)

Role of the complement system in the tumor microenvironment
by: Ronghua Zhang, et al.
Published: (2019-11-01)

Nature vs. Nurture: The Two Opposing Behaviors of Cytotoxic T Lymphocytes in the Tumor Microenvironment
by: Nagaja Capitani, et al.
Published: (2021-10-01)

Exosome-Mediated Immunosuppression in Tumor Microenvironments
by: Qi-Hui Xie, et al.
Published: (2022-06-01)

NK cell exhaustion in the tumor microenvironment
by: Hao Jia, et al.
Published: (2023-11-01)

Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4+Foxp3+ Regulatory T Cells
by: Yuchao Chen, et al.
Published: (2018-09-01)

Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment
by: Li Yang, et al.
Published: (2019-11-01)

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses
by: Alireza Labani-Motlagh, et al.
Published: (2020-05-01)

Phosphorylation of Microglial IRF5 and IRF4 by IRAK4 Regulates Inflammatory Responses to Ischemia
by: Conelius Ngwa, et al.
Published: (2021-01-01)

T Regulatory Cells and Priming the Suppressive Tumor Microenvironment
by: Christina M. Paluskievicz, et al.
Published: (2019-10-01)

Identification of immunosuppressive signature subtypes and prognostic risk signatures in triple-negative breast cancer
by: Ran Ding, et al.
Published: (2023-06-01)

Altered expression of transcription factors IRF4 and IRF8 in peripheral blood B cells is associated with clinical severity and circulating plasma cells frequency in patients with myasthenia gravis
by: Yong Zhang, et al.
Published: (2018-04-01)

Research Status of Tumor-associated Fibroblasts Regulating Immune Cells
by: Guang MU, et al.
Published: (2022-03-01)

Modulation of natural killer cell exhaustion in the lungs: the key components from lung microenvironment and lung tumor microenvironment
by: Hongxia Zhang, et al.
Published: (2023-11-01)

The cross talk between gastric cancer stem cells and the immune microenvironment: a tumor-promoting factor
by: Jared Becerril-Rico, et al.
Published: (2021-09-01)

Immunosuppressive adenosine-targeted biomaterials for emerging cancer immunotherapy
by: Qi Wei, et al.
Published: (2022-10-01)

Modulation of T cell function and survival by the tumor microenvironment
by: Nikita Mani, et al.
Published: (2023-05-01)

Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment
by: Bayley R. McRitchie, et al.
Published: (2022-09-01)

Nebulized Mycobacterium vaccae protects against asthma by attenuating the imbalance of IRF4/IRF8 expression in dendritic cells
by: Qi-Xiang Sun, et al.
Published: (2022-01-01)

Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy
by: Weiqin Jiang, et al.
Published: (2021-02-01)

Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities
by: Yingyue Liu, et al.
Published: (2021-08-01)

Understanding the squamous cell carcinoma immune microenvironment
by: Vahide Saeidi, et al.
Published: (2023-01-01)

Mechanisms and network pharmacological analysis of Yangyin Fuzheng Jiedu prescription in the treatment of hepatocellular carcinoma
by: Yuqing Xie, et al.
Published: (2023-02-01)

Tumor-altered dendritic cell function: implications for anti-tumor immunity
by: Kristian Michael Hargadon
Published: (2013-07-01)

Immune evasion in esophageal squamous cell cancer: From the perspective of tumor microenvironment
by: Rongyang Li, et al.
Published: (2023-01-01)

Pan-cancer landscape of T-cell exhaustion heterogeneity within the tumor microenvironment revealed a progressive roadmap of hierarchical dysfunction associated with prognosis and therapeutic efficacy
by: Zicheng Zhang, et al.
Published: (2022-09-01)

Dose-related immunomodulatory effects of recombinant TRAIL in the tumor immune microenvironment
by: Xupu Wang, et al.
Published: (2023-08-01)

Mediating immunosuppressive functions: a new perspective on the complex immunological properties of SEMA4D in the tumor microenvironment
by: Shujie Zeng, et al.
Published: (2023-05-01)

Interferon Regulatory Factor 4 (IRF4) Plays a Key Role in Osteoblast Differentiation of Postmenopausal Osteoporosis
by: Xuan Wu, et al.
Published: (2024-03-01)

Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction
by: Junchao Zhu, et al.
Published: (2023-12-01)

Multiple influence of immune cells in the bone metastatic cancer microenvironment on tumors
by: Shixin Chen, et al.
Published: (2024-02-01)

Editorial: The immunosuppressive tumor microenvironment and strategies to revert its immune regulatory milieu for cancer immunotherapy
by: Mazdak Ganjalikhani Hakemi, et al.
Published: (2023-06-01)

IRF4 Has a Unique Role in Early B Cell Development and Acts Prior to CD21 Expression to Control Marginal Zone B Cell Numbers
by: Kristina Ottens, et al.
Published: (2021-11-01)

Editorial: Tumor-promoting immune cells: Cancer immune escape and beyond
by: Charlotte Domblides, et al.
Published: (2023-03-01)

Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies
by: Boyuan Huang, et al.
Published: (2023-02-01)

A systematic and comprehensive analysis of T cell exhaustion related to therapy in lung adenocarcinoma tumor microenvironment
by: Peipei Hu, et al.
Published: (2023-02-01)