Splicing factor SRSF1 is essential for CD8 T cell function and host antigen-specific viral immunity

Splicing factor SRSF1 is essential for CD8 T cell function and host antigen-specific viral immunity

Cytotoxic CD8 T cells are crucial for the host antigen-specific immune response to viral pathogens. Here we report the identification of an essential role for the serine/arginine-rich splicing factor (SRSF) 1 in CD8 T cell homeostasis and function. Specifically, SRSF1 is necessary for the maintenanc...

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Bibliographic Details
Main Authors: Ignacio Juarez, Shi Su, Zachary T. Herbert, John R. Teijaro, Vaishali R. Moulton
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
immune response
T cells
cytokines
SRSF1
viral infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.906355/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.906355/full

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