Comprehensive synergy mapping links a BAF- and NSL-containing “supercomplex” to the transcriptional silencing of HIV-1
Summary: Host repressors mediate HIV latency, but how they interactively silence the virus remains unclear. Here, we develop “reiterative enrichment and authentication of CRISPRi targets for synergies (REACTS)” to probe the genome for synergies between HIV transcription repressors. Using eight known...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723010665 |