Morus alba L. (Sangzhi) Alkaloids Promote Insulin Secretion, Restore Diabetic β-Cell Function by Preventing Dedifferentiation and Apoptosis

Morus alba L. (Sangzhi) Alkaloids Promote Insulin Secretion, Restore Diabetic β-Cell Function by Preventing Dedifferentiation and Apoptosis

Background:Morus alba L. (Sangzhi) alkaloids (SZ-A), extracted from the Chinese herb Morus alba L. (mulberry twig), have been shown to ameliorate hyperglycemia in type 2 diabetes and have been approved for diabetes treatment in the clinic. However, their versatile pharmacologic effects and regulator...

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Bibliographic Details
Main Authors: Lei Lei, Yi Huan, Quan Liu, Caina Li, Hui Cao, Wenming Ji, Xuefeng Gao, Yaxin Fu, Pingping Li, Ruiping Zhang, Zeper Abliz, Yuling Liu, Shuainan Liu, Zhufang Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
morus alba L. (Sangzhi) alkaloids
type 2 diabetes
islet β cells
insulin secretion
apoptosis
dedifferentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.841981/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.841981/full

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