Endoplasmic Reticulum Stress Affects Cholesterol Homeostasis by Inhibiting LXRα Expression in Hepatocytes and Macrophages

Endoplasmic Reticulum Stress Affects Cholesterol Homeostasis by Inhibiting LXRα Expression in Hepatocytes and Macrophages

Atherosclerosis (AS) is the most common cardiovascular disease, and reverse cholesterol transport (RCT) plays an important role in maintaining cholesterol homeostasis. Both endoplasmic reticulum (ER) stress and LXRα can affect the metabolism of cholesterol. However, whether ER stress can modulate ch...

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Bibliographic Details
Main Authors: Tian Wang, Yiyang Zhao, Zhongsheng You, Xiatian Li, Mingdi Xiong, Hua Li, Nianlong Yan
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Nutrients
Subjects:
endoplasmic reticulum stress
LXRα
cholesterol metabolism
atherosclerosis
reverse cholesterol transport
Online Access:https://www.mdpi.com/2072-6643/12/10/3088

Internet

https://www.mdpi.com/2072-6643/12/10/3088

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