Expression of the Ebola Virus VP24 Protein Compromises the Integrity of the Nuclear Envelope and Induces a Laminopathy-Like Cellular Phenotype

Expression of the Ebola Virus VP24 Protein Compromises the Integrity of the Nuclear Envelope and Induces a Laminopathy-Like Cellular Phenotype

ABSTRACT Ebola virus (EBOV) VP24 protein is a nucleocapsid-associated protein that inhibits interferon (IFN) gene expression and counteracts the IFN-mediated antiviral response, preventing nuclear import of signal transducer and activator of transcription 1 (STAT1). Proteomic studies to identify add...

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Bibliographic Details
Main Authors: Santiago Vidal, Maite Sánchez-Aparicio, Rocío Seoane, Ahmed El Motiam, Emily V. Nelson, Yanis H. Bouzaher, Maite Baz-Martínez, Isabel García-Dorival, Susana Gonzalo, Enrique Vázquez, Anxo Vidal, César Muñoz-Fontela, Adolfo García-Sastre, Carmen Rivas
Format: Article
Language:English
Published: American Society for Microbiology 2021-08-01
Series:mBio
Subjects:
Ebola virus
laminopathies
nuclear envelope
virus-host interactions
Online Access:https://journals.asm.org/doi/10.1128/mBio.00972-21

Internet

https://journals.asm.org/doi/10.1128/mBio.00972-21

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