Targeting HER3 or MEK overcomes acquired Trastuzumab resistance in HER2-positive gastric cancer-derived xenograft

Targeting HER3 or MEK overcomes acquired Trastuzumab resistance in HER2-positive gastric cancer-derived xenograft

Abstract Acquired Trastuzumab resistance is a complicated and disastrous event for HER2-positive gastric cancer (GC). In this study, we successfully established a GC PDX model with Trastuzumab sensitivity (176P) and induced a homologous model with acquired Trastuzumab resistance (176R), then compreh...

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Bibliographic Details
Main Authors: Mengqi Zhang, Beifang Li, Haiyan Liao, Zuhua Chen, Wenwen Huang, Jing Yang, Sai Ge, Zhongwu Li, Lin Shen, Cheng Zhang, Jing Gao
Format: Article
Language:English
Published: Nature Publishing Group 2022-12-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01259-z

Internet

https://doi.org/10.1038/s41420-022-01259-z

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