Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes

Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes

The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome in podocytes has been implicated in the initiation of glomerular inflammation during hyperhomocysteinemia (hHcy). However, the mechanism by which NLRP3 inflammasome products are released from p...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän:	Guangbi Li, Dandan Huang, Ningjun Li, Joseph K. Ritter, Pin-Lan Li
Materialtyp:	Artikel
Språk:	English
Publicerad:	Elsevier 2021-07-01
Serie:	Redox Biology
Ämnen:	Podocyte Homocysteine Reactive oxygen species TRPML1 channel Exosome Lysosome
Länkar:	http://www.sciencedirect.com/science/article/pii/S2213231721001713

Liknande verk

TRPML1—Emerging Roles in Cancer
av: Yiming Yang, et al.
Publicerad: (2020-12-01)

Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells
av: Eva Plesch, et al.
Publicerad: (2018-11-01)

TRPML Cation Channels in Inflammation and Immunity
av: Barbara Spix, et al.
Publicerad: (2020-02-01)

Modulation of Cisplatin Sensitivity through TRPML1-Mediated Lysosomal Exocytosis in Ovarian Cancer Cells: A Comprehensive Metabolomic Approach
av: Boyun Kim, et al.
Publicerad: (2024-01-01)

Modulation of Lysosomal Cl<sup>−</sup> Mediates Migration and Apoptosis through the TRPML1 as a Lysosomal Cl<sup>−</sup> Sensor
av: Dongun Lee, et al.
Publicerad: (2023-07-01)

The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity
av: Jingjing Zhang, et al.
Publicerad: (2023-01-01)

Zinc oxide nanoparticles trigger autophagy-mediated cell death through activating lysosomal TRPML1 in normal kidney cells
av: Boyun Kim, et al.
Publicerad: (2023-01-01)

ZEB1-AS1 as a TRPML1 Inhibitor to Cause Lysosome Dysfunction and Cardiac Damage in Aged Mice
av: Heng Liu, et al.
Publicerad: (2024-12-01)

Lysosomal TRPML1 triggers global Ca2+ signals and nitric oxide release in human cerebrovascular endothelial cells
av: Valentina Brunetti, et al.
Publicerad: (2024-06-01)

Enhanced Epithelial-to-Mesenchymal Transition Associated with Lysosome Dysfunction in Podocytes: Role of p62/Sequestosome 1 as a Signaling Hub
av: Guangbi Li, et al.
Publicerad: (2015-03-01)

Effect of Sirt1 on high glucose-induced exosome release from podocytes
av: DING Lin, ZHOU Yan, LIU Shanshan, LIU Nanchi, MA Ruixia
Publicerad: (2024-02-01)

TRPML1 gating modulation by allosteric mutations and lipids
av: Ninghai Gan, et al.
Publicerad: (2024-10-01)

Lysosomal Ca2+ release-facilitated TFEB nuclear translocation alleviates ischemic brain injury by attenuating autophagic/lysosomal dysfunction in neurons
av: Qian Lei, et al.
Publicerad: (2024-10-01)

Research progress on exosomes in podocyte injury associated with diabetic kidney disease
av: Jiao Li, et al.
Publicerad: (2023-03-01)

Aza Analogs of the TRPML1 Inhibitor Estradiol Methyl Ether (EDME)
av: Philipp Rühl, et al.
Publicerad: (2023-11-01)

Proteomics analysis of a human brain sample from a mucolipidosis type IV patient reveals pathophysiological pathways
av: Ayelet Vardi, et al.
Publicerad: (2021-01-01)

The Mucolipin TRPML2 Channel Enhances the Sensitivity of Multiple Myeloma Cell Lines to Ibrutinib and/or Bortezomib Treatment
av: Giorgio Santoni, et al.
Publicerad: (2022-01-01)

Podocyte Pathology and Nephropathy
av: Barbara eLewko, et al.
Publicerad: (2015-09-01)

Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma
av: Wanlu Du, et al.
Publicerad: (2021-10-01)

Exosomes secreted by podocytes regulate the differentiation of Th17/Treg cells in idiopathic nephrotic syndrome
av: Yang Jia, et al.
Publicerad: (2024-09-01)

Endolysosomal transient receptor potential mucolipins and two-pore channels: implications for cancer immunity
av: Lina Ouologuem, et al.
Publicerad: (2024-05-01)

Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
av: Sensen Zhang, et al.
Publicerad: (2017-09-01)

TRPML1 as a potential therapeutic target for triple-negative breast cancer: a review
av: Ying Pan, et al.
Publicerad: (2023-12-01)

Activated Endolysosomal Cation Channel TRPML1 Facilitates Maturation of α-Synuclein-Containing Autophagosomes
av: Maike R. Pollmanns, et al.
Publicerad: (2022-07-01)

Blunting ROS/TRPML1 pathway protects AFB1-induced porcine intestinal epithelial cells apoptosis by restoring impaired autophagic flux
av: Xinyi Cheng, et al.
Publicerad: (2023-06-01)

Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma
av: Carla Abrahamian, et al.
Publicerad: (2021-07-01)

Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury
av: Ying Liu, et al.
Publicerad: (2020-10-01)

Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagy
av: Mariana I. Capurro, et al.
Publicerad: (2023-12-01)

TRPML1 Participates in the Progression of Alzheimer’s Disease by Regulating the PPARγ/AMPK/Mtor Signalling Pathway
av: Lu Zhang, et al.
Publicerad: (2017-10-01)

Early evidence of delayed oligodendrocyte maturation in the mouse model of mucolipidosis type IV
av: Molly Mepyans, et al.
Publicerad: (2020-07-01)

Nanoparticles encapsulating phosphatidylinositol derivatives promote neuroprotection and functional improvement in preclinical models of ALS via a long-lasting activation of TRPML1 lysosomal channel
av: Valentina Tedeschi, et al.
Publicerad: (2024-12-01)

Pathophysiological Role of Transient Receptor Potential Mucolipin Channel 1 in Calcium-Mediated Stress-Induced Neurodegenerative Diseases
av: Giorgio Santoni, et al.
Publicerad: (2020-03-01)

Use and isolation of urinary exosomes as biomarkers for diabetic nephropathy
av: Luca eMusante, et al.
Publicerad: (2014-09-01)

Endolysosomal Cation Channels and Lung Disease
av: Barbara Spix, et al.
Publicerad: (2022-01-01)

Neurodegenerative Lysosomal Storage Disorders: TPC2 Comes to the Rescue!
av: Sandra Prat Castro, et al.
Publicerad: (2022-09-01)

Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction
av: Leonardo Ermini, et al.
Publicerad: (2021-05-01)

Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte
av: Juan Jin, et al.
Publicerad: (2019-03-01)

Effects of a novel ANLN E841K mutation associated with SRNS on podocytes and its mechanism
av: Li Lin, et al.
Publicerad: (2023-11-01)

Urinary podocyte microparticles are associated with disease activity and renal injury in systemic lupus erythematosus
av: Jian Lu, et al.
Publicerad: (2019-08-01)

Cyclosporine A Protects Podocytes by Regulating Transgelin in Adriamycin-Induced Podocyte Injury
av: Xiaoyan Li, et al.
Publicerad: (2024-07-01)