Peripheral CB1 Receptor Neutral Antagonist, AM6545, Ameliorates Hypometabolic Obesity and Improves Adipokine Secretion in Monosodium Glutamate Induced Obese Mice

Peripheral CB1 Receptor Neutral Antagonist, AM6545, Ameliorates Hypometabolic Obesity and Improves Adipokine Secretion in Monosodium Glutamate Induced Obese Mice

Effect of peripheral cannabinoid receptor 1 (CB1R) blockade by AM6545 in the monosodium glutamate (MSG)-induced hypometabolic and hypothalamic obesity was observed, and the impact on intraperitoneal adipose tissue and adipokines was investigated. The MSG mice is characterized by excessive abdominal...

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Bibliographic Details
Main Authors: Haiming Ma, Guina Zhang, Chunrong Mou, Xiujuan Fu, Yadan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
CB1 receptor
AM6545
peripheral
obesity
antagonist
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00156/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00156/full

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