Detection of IDH mutation in glioma by desorption electrospray ionization (DESI) tandem mass spectrometry

Detection of IDH mutation in glioma by desorption electrospray ionization (DESI) tandem mass spectrometry

Abstract Desorption electrospray ionization (DESI) tandem mass spectrometry (MS) is used to assess mutation status of isocitrate dehydrogenase (IDH) in human gliomas. Due to the diffuse nature of gliomas, total gross resection is not normally achieved during surgery, leading to tumor recurrence. The...

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Bibliographic Details
Main Authors: Mahdiyeh Shahi, Steven Pringle, Michael Morris, Diogo Moniz Garcia, Alfredo Quiñones-Hinojosa, R. Graham Cooks
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Multiple reaction monitoring (MRM)
2-hydroxyglutarate
Oncometabolite
Molecular diagnostics
Brain cancer
Ambient ionization
Online Access:https://doi.org/10.1038/s41598-024-77044-y

Internet

https://doi.org/10.1038/s41598-024-77044-y

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