Fliposomes: pH-Sensitive Liposomes Containing a trans-2-morpholinocyclohexanol-Based Lipid That Performs a Conformational Flip and Triggers an Instant Cargo Release in Acidic Medium

Fliposomes: pH-Sensitive Liposomes Containing a trans-2-morpholinocyclohexanol-Based Lipid That Performs a Conformational Flip and Triggers an Instant Cargo Release in Acidic Medium

Incorporation of a pH-sensitive conformational switch into a lipid structure enables a drastic conformational flip upon protonation that disrupts the liposome membrane and causes rapid release of cargo specifically in areas of increased acidity. pH-sensitive liposomes containing the amphiphile (1) w...

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Bibliographic Details
Main Authors: Barbora Brazdova, Andreas H. Franz, Vyacheslav V. Samoshin, Xin Guo, Xin Liu, Nataliya M. Samoshina
Format: Article
Language:English
Published: MDPI AG 2011-07-01
Series:Pharmaceutics
Subjects:
pH-sensitive liposomes
fliposomes
polyethyleneglycol (PEG)
conformational switch
controlled drug release
triggered release
Online Access:http://www.mdpi.com/1999-4923/3/3/379/

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http://www.mdpi.com/1999-4923/3/3/379/

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