Allele-dependent interaction of LRRK2 and NOD2 in leprosy.

Allele-dependent interaction of LRRK2 and NOD2 in leprosy.

Leprosy, caused by Mycobacterium leprae, rarely affects children younger than 5 years. Here, we studied a multiplex leprosy family that included monozygotic twins aged 22 months suffering from paucibacillary leprosy. Whole genome sequencing identified three amino acid mutations previously associated...

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Bibliographic Details
Main Authors: Monica Dallmann-Sauer, Yong Zhong Xu, Ana Lúcia França da Costa, Shao Tao, Tiago Araujo Gomes, Rhana Berto da Silva Prata, Wilian Correa-Macedo, Jérémy Manry, Alexandre Alcaïs, Laurent Abel, Aurélie Cobat, Vinicius M Fava, Roberta Olmo Pinheiro, Flavio Alves Lara, Christian M Probst, Marcelo T Mira, Erwin Schurr
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011260

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https://doi.org/10.1371/journal.ppat.1011260

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