Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia

ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling. Gliomas with increased <i>ARL13B</i>, <i>S...

Full description

Bibliographic Details
Main Authors: Ping Shi, Jia Tian, Julianne C. Mallinger, Dahao Ling, Loic P. Deleyrolle, Jeremy C. McIntyre, Tamara Caspary, Joshua J. Breunig, Matthew R. Sarkisian
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cells
Subjects:
primary cilia
hedgehog
glioblastoma
GLI2
smoothened
vismodegib
Online Access:https://www.mdpi.com/2073-4409/12/19/2354

Internet

https://www.mdpi.com/2073-4409/12/19/2354

Similar Items